Abstract
Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the Aβ(25-35) induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adrenal Gland Neoplasms / chemically induced
-
Adrenal Gland Neoplasms / drug therapy*
-
Amyloid beta-Peptides
-
Animals
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Antineoplastic Agents, Phytogenic / therapeutic use*
-
Dipsacaceae / chemistry*
-
Humans
-
Molecular Structure
-
PC12 Cells
-
Peptide Fragments
-
Pheochromocytoma / chemically induced
-
Pheochromocytoma / drug therapy*
-
Phytotherapy
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Plant Extracts / therapeutic use
-
Plant Roots / chemistry
-
Rats
-
Saponins / isolation & purification
-
Saponins / pharmacology
-
Saponins / therapeutic use*
Substances
-
3-O-(3',4'-O-acetyl)-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside
-
3-O-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside (3-C-28)
-
3-O-arabinopyranosyl oleanolic acid
-
Amyloid beta-Peptides
-
Antineoplastic Agents, Phytogenic
-
Peptide Fragments
-
Plant Extracts
-
Saponins