A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles

Feng Zhou; Miao Ding; Jian Zhou

doi:10.1039/c2ob25319d

A catalytic metal-free Ritter reaction to 3-substituted 3-aminooxindoles

Org Biomol Chem. 2012 Apr 28;10(16):3178-81. doi: 10.1039/c2ob25319d. Epub 2012 Mar 20.

Authors

Feng Zhou¹, Miao Ding, Jian Zhou

Affiliation

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, PR China.

PMID: 22430824
DOI: 10.1039/c2ob25319d

Abstract

The first Ritter reaction of 3-substituted 3-hydroxyoxindoles with nitriles, catalyzed by HClO(4), is developed, which enables the synthesis of 3-substituted 3-aminooxindoles in good to excellent yield with rich diversity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemical synthesis
Amines / chemistry*
Catalysis
Hypochlorous Acid / chemistry
Indoles / chemical synthesis
Indoles / chemistry*
Nitriles / chemical synthesis
Nitriles / chemistry*
Oxindoles

Substances

Amines
Indoles
Nitriles
Oxindoles
2-oxindole
Hypochlorous Acid