Large vessels recanalization is a challenge for mechanical atherectomy devices, where the lumen debulked is close in diameter to the device crossing profile, which may be only 25% to 30% of the original lumen size; so, the procedure can restore only a fraction of the original blood flow. Moreover, small diameter lumens are prone to be repeatedly occluded after a relatively short period of time. In this article, we present a novel technology of recanalization, using a catheter-based microjet system to deliver a flux of biocompatible abrasive particles to the lesion site, resulting in microchipping of the plaque, while minimizing trauma to the vessel wall. Plaque debris is removed from the blood flow, and blood flow is restored. In contrast to rotating mechanical devices, plaque debulking can be performed up to diameters that are substantially larger than the device crossing profile, supporting superior long-term patency. As a case study, we evaluated the technology for use in the superficial femoral artery where the lesions tend to be very long and heavily calcified with high restenosis rates.