ALK and MYCN: when two oncogenes are better than one

Cancer Cell. 2012 Mar 20;21(3):325-6. doi: 10.1016/j.ccr.2012.03.004.

Abstract

Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.

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