Translational advances in pain and anesthesia for cancer patients

J Surg Oncol. 2012 Apr 1;105(5):488-93. doi: 10.1002/jso.21853.

Abstract

Effective cancer pain management requires multidisciplinary approaches for multimodal analgesia. Although opioids have been the cornerstone, developments such as regional anesthesia and interventional pain techniques, complementary and alternative medicine, and new pharmaceuticals also have shown promise to relieve cancer pain. This overview of relevant clinical efforts and the modern day state of the science will afford a better understanding of pain mechanisms and multimodal approaches beneficial in optimizing analgesia for cancer patients.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Analgesics / pharmacology
  • Analgesics / therapeutic use
  • Anesthesia / methods*
  • Anesthesia / trends
  • Chronic Disease
  • Codon, Nonsense / drug effects
  • Cytochrome P-450 CYP2D6 / genetics
  • Drugs, Investigational / pharmacology
  • Drugs, Investigational / therapeutic use
  • Genotype
  • Humans
  • NAV1.7 Voltage-Gated Sodium Channel
  • Neoplasms / complications*
  • Neoplasms / surgery*
  • Pain / drug therapy*
  • Pain / etiology
  • Pain / genetics*
  • Pain Management / methods*
  • Pain Management / trends
  • Polymorphism, Single Nucleotide / drug effects
  • Quality of Life
  • Sodium Channels / genetics
  • Translational Research, Biomedical / trends*

Substances

  • Analgesics
  • Codon, Nonsense
  • Drugs, Investigational
  • NAV1.7 Voltage-Gated Sodium Channel
  • SCN9A protein, human
  • Sodium Channels
  • Cytochrome P-450 CYP2D6