Sonic hedgehog, BOC, and synaptic development: new players for an old game

Julien Courchet; Franck Polleux

doi:10.1016/j.neuron.2012.03.008

Sonic hedgehog, BOC, and synaptic development: new players for an old game

Neuron. 2012 Mar 22;73(6):1055-8. doi: 10.1016/j.neuron.2012.03.008. Epub 2012 Mar 21.

Authors

Julien Courchet¹, Franck Polleux

Affiliation

¹ Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

PMID: 22445332
DOI: 10.1016/j.neuron.2012.03.008

Abstract

In this issue of Neuron, Harwell et al. (2012) identify a new role for the secreted molecule Shh and its receptor Boc in synapse formation. These results add an unexpected new player to the expanding list of extracellular cues regulating the spatial specificity of synapse formation.

Publication types

Comment

MeSH terms

Animals
Cerebral Cortex / cytology*
Gene Expression Regulation, Developmental / physiology*
Hedgehog Proteins / metabolism*
Nerve Net / metabolism*
Neurons / metabolism*
Pyramidal Tracts / physiology*

Substances

Hedgehog Proteins
Shh protein, mouse