Abstract
Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Cell Line
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Citrus / chemistry*
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Cyclic Nucleotide Phosphodiesterases, Type 1 / antagonists & inhibitors
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Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Flavonoids / therapeutic use
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Glycosides / chemistry
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Glycosides / pharmacology*
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Glycosides / therapeutic use
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Inflammation / chemically induced
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Inflammation / drug therapy
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology*
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Macrophages / drug effects*
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Mice
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Phosphodiesterase 4 Inhibitors / chemistry
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Phosphodiesterase 4 Inhibitors / pharmacology*
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Phosphodiesterase 4 Inhibitors / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Flavonoids
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Glycosides
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Lipopolysaccharides
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Phosphodiesterase 4 Inhibitors
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sudachitin
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Cyclic Nucleotide Phosphodiesterases, Type 1
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Cyclic Nucleotide Phosphodiesterases, Type 4