Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes

Martin Teichmann; Hélène Dumay-Odelot; Sébastien Fribourg

doi:10.4161/trns.3.1.18917

Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes

Transcription. 2012 Jan-Feb;3(1):2-7. doi: 10.4161/trns.3.1.18917.

Authors

Martin Teichmann¹, Hélène Dumay-Odelot, Sébastien Fribourg

Affiliation

¹ Université de Bordeaux, Institut Européen de Chimie et Biologie, Pessac, France.

PMID: 22456313
DOI: 10.4161/trns.3.1.18917

Abstract

The winged helix (WH) domain is found in core components of transcription systems in eukaryotes and prokaryotes. It represents a sub-class of the helix-turn-helix motif. The WH domain participates in establishing protein-DNA and protein-protein-interactions. Here, we discuss possible explanations for the enrichment of this motif in transcription systems.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry
DNA / metabolism
DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / metabolism
DNA-Directed RNA Polymerases / chemistry*
DNA-Directed RNA Polymerases / metabolism
Helix-Turn-Helix Motifs
Humans
Protein Structure, Tertiary
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / chemistry
Saccharomyces cerevisiae Proteins / metabolism
Transcription Factors / chemistry*
Transcription Factors / metabolism
Transcription, Genetic

Substances

DNA-Binding Proteins
Saccharomyces cerevisiae Proteins
Transcription Factors
DNA
DNA-Directed RNA Polymerases