Efficient construction of fused indolines with a 2-quaternary center via an intramolecular Heck reaction with a low catalyst loading

Lei Zhao; Ziyuan Li; Lin Chang; Jinyi Xu; Hequan Yao; Xiaoming Wu

doi:10.1021/ol300584m

Efficient construction of fused indolines with a 2-quaternary center via an intramolecular Heck reaction with a low catalyst loading

Org Lett. 2012 Apr 20;14(8):2066-9. doi: 10.1021/ol300584m. Epub 2012 Mar 30.

Authors

Lei Zhao¹, Ziyuan Li, Lin Chang, Jinyi Xu, Hequan Yao, Xiaoming Wu

Affiliation

¹ State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.

PMID: 22463710
DOI: 10.1021/ol300584m

Abstract

An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure
Palladium / chemistry*

Substances

Indoles
Palladium
indoline