Abstract
We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Base Sequence
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Bone Marrow Transplantation / adverse effects*
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Chromosomes, Human, X / genetics
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Chromosomes, Human, Y / genetics
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Chronic Disease
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DNA, Viral / genetics
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Epstein-Barr Virus Infections / etiology*
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Epstein-Barr Virus Infections / genetics
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Epstein-Barr Virus Infections / therapy*
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Epstein-Barr Virus Infections / virology
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Female
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Lupus Erythematosus, Systemic / complications
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Lymphoproliferative Disorders / etiology
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / therapy
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Lymphoproliferative Disorders / virology
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Male
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Recurrence
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T-Lymphocytes / virology
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Tissue Donors
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Transplantation, Homologous