Cell division control by the Chromosomal Passenger Complex

Maike S van der Waal; Rutger C C Hengeveld; Armando van der Horst; Susanne M A Lens

doi:10.1016/j.yexcr.2012.03.015

Cell division control by the Chromosomal Passenger Complex

Exp Cell Res. 2012 Jul 15;318(12):1407-20. doi: 10.1016/j.yexcr.2012.03.015. Epub 2012 Mar 24.

Authors

Maike S van der Waal¹, Rutger C C Hengeveld, Armando van der Horst, Susanne M A Lens

Affiliation

¹ Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

PMID: 22472345
DOI: 10.1016/j.yexcr.2012.03.015

Abstract

The Chromosomal Passenger Complex (CPC) consisting of Aurora B kinase, INCENP, Survivin and Borealin, is essential for genomic stability by controlling multiple processes during both nuclear and cytoplasmic division. In mitosis it ensures accurate segregation of the duplicated chromosomes by regulating the mitotic checkpoint, destabilizing incorrectly attached spindle microtubules and by promoting the axial shortening of chromosomal arms in anaphase. During cytokinesis the CPC most likely prevents chromosome damage by imposing an abscission delay when a chromosome bridge connects the two daughter cells. Moreover, by controlling proper cytoplasmic division, the CPC averts tetraploidization. This review describes recent insights on how the CPC is capable of conducting its various functions in the dividing cell to ensure chromosomal stability.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Aurora Kinase B
Aurora Kinases
Cell Cycle / genetics
Cell Cycle / physiology
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
Cell Cycle Proteins / physiology
Cell Division / genetics*
Cell Division / physiology
Chromosomal Proteins, Non-Histone / genetics
Chromosomal Proteins, Non-Histone / metabolism
Chromosomal Proteins, Non-Histone / physiology*
Cytokinesis / genetics
Cytokinesis / physiology
Humans
Inhibitor of Apoptosis Proteins / genetics
Inhibitor of Apoptosis Proteins / metabolism
Inhibitor of Apoptosis Proteins / physiology
Models, Biological
Multiprotein Complexes / genetics
Multiprotein Complexes / metabolism
Multiprotein Complexes / physiology*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Protein Serine-Threonine Kinases / physiology
Survivin

Substances

BIRC5 protein, human
CDCA8 protein, human
Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
INCENP protein, human
Inhibitor of Apoptosis Proteins
Multiprotein Complexes
Survivin
AURKB protein, human
Aurora Kinase B
Aurora Kinases
Protein Serine-Threonine Kinases