Abstract
Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Cycle Proteins / physiology*
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Cell Nucleus / genetics
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Cell Nucleus / metabolism
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Cell Nucleus / ultrastructure
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Chromosomal Proteins, Non-Histone / physiology*
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Chromosomes / chemistry*
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Chromosomes / genetics
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Chromosomes / metabolism
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Chromosomes / ultrastructure
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Cohesins
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Humans
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Interphase / genetics
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Interphase / physiology
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Meiosis / genetics
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Meiosis / physiology
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Mitosis / genetics
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Mitosis / physiology
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Models, Biological
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Nucleic Acid Conformation
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Sister Chromatid Exchange / genetics
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Sister Chromatid Exchange / physiology
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone