Abstract
Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects*
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Cell Survival / drug effects
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Cells, Cultured
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Dose-Response Relationship, Drug
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Human Umbilical Vein Endothelial Cells / drug effects*
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Human Umbilical Vein Endothelial Cells / pathology
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Humans
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Hydrogenation
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phytosterols / chemical synthesis
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Phytosterols / pharmacology*
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Structure-Activity Relationship