Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adoptive Transfer
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Animals
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Antigen Presentation
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Biomarkers / analysis
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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Graft Rejection / immunology
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Graft Rejection / prevention & control*
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Granulocytes / cytology
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Granulocytes / immunology
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Granulocytes / transplantation
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Humans
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Immune Tolerance*
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Mice
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Monocytes / cytology
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Monocytes / immunology
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Monocytes / transplantation
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Myeloid Cells / cytology
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Myeloid Cells / immunology*
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Myeloid Cells / transplantation
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Organ Transplantation*
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T-Lymphocytes, Regulatory / cytology
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T-Lymphocytes, Regulatory / immunology
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Transplantation, Homologous