In epigenetic therapy, less is more

Hui Shen; Peter W Laird

doi:10.1016/j.stem.2012.03.012

In epigenetic therapy, less is more

Cell Stem Cell. 2012 Apr 6;10(4):353-4. doi: 10.1016/j.stem.2012.03.012.

Authors

Hui Shen¹, Peter W Laird

Affiliation

¹ USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9601, USA.

PMID: 22482500
DOI: 10.1016/j.stem.2012.03.012

Abstract

How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells.

Publication types

Comment