Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics

Methods Cell Biol. 2012:110:367-88. doi: 10.1016/B978-0-12-388403-9.00014-X.

Abstract

A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through "fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blood Coagulation / physiology*
  • Blood Coagulation Factors / metabolism
  • Blood Platelets / cytology*
  • Blood Platelets / metabolism
  • Computer Simulation
  • Fibrin / metabolism
  • Fluorescent Dyes
  • Hemorheology
  • Mathematical Computing
  • Mice
  • Microscopy, Fluorescence, Multiphoton
  • Models, Biological*
  • Models, Molecular*
  • Platelet Adhesiveness
  • Surface Properties
  • Thrombin / metabolism

Substances

  • Blood Coagulation Factors
  • Fluorescent Dyes
  • Fibrin
  • Thrombin