Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai

Bioorg Med Chem Lett. 2012 May 1;22(9):3126-9. doi: 10.1016/j.bmcl.2012.03.058. Epub 2012 Mar 20.

Abstract

Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC(50) values in the range of 0.5-30 μM. The cytochalasin B (5) showed obvious cytotoxicity with IC(50) of 7.9 μM against HeLa human cervical carcinoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Ascomycota / chemistry*
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Cytochalasins / chemistry
  • Cytochalasins / pharmacology*
  • Dose-Response Relationship, Drug
  • Early Detection of Cancer
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Scyphozoa / microbiology*

Substances

  • Antineoplastic Agents
  • Cytochalasins