Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species

Boram Lee; Ki Hyun Kim; Hye Jin Jung; Ho Jeong Kwon

doi:10.1016/j.bbrc.2012.03.114

Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species

Biochem Biophys Res Commun. 2012 Apr 27;421(1):76-80. doi: 10.1016/j.bbrc.2012.03.114. Epub 2012 Mar 28.

Authors

Boram Lee¹, Ki Hyun Kim, Hye Jin Jung, Ho Jeong Kwon

Affiliation

¹ Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center for Protein Function Control, College of Life Science & Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.

PMID: 22483751
DOI: 10.1016/j.bbrc.2012.03.114

Abstract

Mitochondrial reactive oxygen species (mROS) are involved in cancer initiation and progression and function as signaling molecules in many aspects of hypoxia and growth factor-mediated signaling. Here we report that matairesinol, a natural small molecule identified from the cell-based screening of 200 natural plants, suppresses mROS generation resulting in anti-angiogenic activity. A non-toxic concentration of matairesinol inhibited the proliferation of human umbilical vein endothelial cells. The compound also suppressed in vitro angiogenesis of tube formation and chemoinvasion, as well as in vivo angiogenesis of the chorioallantoic membrane at non-toxic doses. Furthermore, matairesinol decreased hypoxia-inducible factor-1α in hypoxic HeLa cells. These results demonstrate that matairesinol could function as a novel angiogenesis inhibitor by suppressing mROS signaling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / pharmacology*
Cedrus / chemistry
Furans / chemistry
Furans / pharmacology*
HeLa Cells
Human Umbilical Vein Endothelial Cells / drug effects
Human Umbilical Vein Endothelial Cells / metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Lignans / chemistry
Lignans / pharmacology*
Mitochondria / drug effects*
Mitochondria / metabolism
Neovascularization, Pathologic / metabolism
Neovascularization, Physiologic / drug effects
Plant Extracts / chemistry
Plant Extracts / pharmacology
Protein Stability
Reactive Oxygen Species / antagonists & inhibitors*
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Vascular Endothelial Growth Factor A / genetics

Substances

Angiogenesis Inhibitors
Furans
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
Lignans
Plant Extracts
Reactive Oxygen Species
Vascular Endothelial Growth Factor A
matairesinol