Abstract
We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n=13, <3 years prior to diagnosis) when compared with HIV-negative (n=18) or HIV-positive controls (n=21) (P<0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD40 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.
Publication types
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Multicenter Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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B-Lymphocytes / immunology*
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Biomarkers, Tumor
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CD40 Antigens / physiology
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Case-Control Studies
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HIV Infections / immunology*
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HIV Seropositivity
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Humans
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Immunoglobulin M / physiology
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Interleukin-4 / physiology
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Lipopolysaccharides / physiology
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Lymphoma, AIDS-Related / immunology*
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Male
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MicroRNAs / metabolism*
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Palatine Tonsil / immunology
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Prospective Studies
Substances
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Biomarkers, Tumor
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CD40 Antigens
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Immunoglobulin M
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Lipopolysaccharides
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MicroRNAs
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Interleukin-4