Amide-directed tandem C-C/C-N bond formation through C-H activation

Chem Asian J. 2012 Jun;7(7):1502-14. doi: 10.1002/asia.201200035. Epub 2012 Apr 11.

Abstract

The transformation of C-H bonds into other chemical bonds is of great significance in synthetic chemistry. C-H bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C-H activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C-N bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem C-C/C-N bond-formation process through C-H activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkenes / chemistry
  • Alkynes / chemistry
  • Amides / chemistry*
  • Carbon Monoxide / chemistry
  • Cyanides / chemistry
  • Hydrocarbons, Aromatic / chemistry*

Substances

  • Alkenes
  • Alkynes
  • Amides
  • Cyanides
  • Hydrocarbons, Aromatic
  • Carbon Monoxide