Abstract
Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Axons / pathology*
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Calcium / metabolism*
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Disease Models, Animal*
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Drosophila Proteins / metabolism*
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Drosophila melanogaster*
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Humans
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Mitochondria / metabolism*
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Nerve Tissue Proteins / metabolism*
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Nicotinamide-Nucleotide Adenylyltransferase / metabolism*
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Wallerian Degeneration / genetics*
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Wallerian Degeneration / metabolism*
Substances
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Drosophila Proteins
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Nerve Tissue Proteins
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Wld protein, mouse
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Nicotinamide-Nucleotide Adenylyltransferase
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Calcium