Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage

J Neuroimmunol. 2012 Jun 15;247(1-2):75-80. doi: 10.1016/j.jneuroim.2012.03.019. Epub 2012 Apr 11.

Abstract

Inflammatory response in intracerebral hemorrhage (ICH) is associated with poor outcome and could be a consequence of Toll-like receptor (TLR) activation. We investigated the influence of TLR2 and TLR4 expression on the outcome of ICH patients. Expression levels of TLR2 and TLR4 in monocytes at admission were independently associated with poor functional outcome. On the other hand, TLR2 and TLR4 expression at admission in both monocytes and neutrophils was independently associated with residual lesion volume. In conclusion, increased expression of TLR2 and TLR4 is associated with poor functional outcome and greater residual volume in ICH patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cerebral Hemorrhage / metabolism*
  • Cerebral Hemorrhage / pathology*
  • Electrocardiography
  • Female
  • Gene Expression Regulation / physiology
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • Neutrophils / metabolism*
  • Prospective Studies
  • Retrospective Studies
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Toll-Like Receptor 2 / metabolism*
  • Toll-Like Receptor 4 / metabolism*
  • Tomography, X-Ray Computed

Substances

  • Toll-Like Receptor 2
  • Toll-Like Receptor 4