Recurrence from primary and secondary glomerulopathy after renal transplant

Transpl Int. 2012 Aug;25(8):812-24. doi: 10.1111/j.1432-2277.2012.01483.x. Epub 2012 Apr 16.

Abstract

Glomerulonephritis is the primary cause of end-stage renal failure in 30-50% of kidney transplant recipients and recurrence of the initial disease is an important determinant of long-term graft outcome after transplantation. Although renal transplantation remains the best treatment option for patients with end stage renal diseases in most cases, diagnosis and management of recurrences of glomerulopathies are critical for the optimization and improvement of long-term kidney transplant graft survival and provide a unique opportunity to explore the pathogenesis of native kidney disease. This review aims to update knowledge for a large panel of recurrent primary and secondary glomerulonephritis after kidney transplantation, excluding diabetic nephropathy including primary focal and segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy, membranoproliferative glomerulonephritis, lupus, vasculitis but also less usual secondary nephropathy related to sarcoidosis, AA and AL amyloidosis, monoclonal immunoglobulin deposition disease, and fibrillary glomerulonephritis.

Publication types

  • Review

MeSH terms

  • Adult
  • Amyloidosis / complications
  • Anti-Glomerular Basement Membrane Disease / complications
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / complications
  • Antiphospholipid Syndrome / complications
  • Child
  • Glomerulonephritis / complications*
  • Glomerulonephritis, IGA / complications
  • Glomerulonephritis, Membranoproliferative / complications
  • Glomerulonephritis, Membranous / complications
  • Glomerulosclerosis, Focal Segmental / physiopathology
  • Graft Survival
  • Humans
  • IgA Vasculitis / complications
  • Kidney Diseases / complications
  • Kidney Failure, Chronic / etiology*
  • Kidney Transplantation / adverse effects*
  • Lupus Erythematosus, Systemic / complications
  • Recurrence

Supplementary concepts

  • Segmental glomerulosclerosis