Abstract
Over the past few years and with the use of innovative genomic and proteomic tools, several molecules that their urinary concentration is modified during acute kidney injury have been identified and proposed as biomarkers. Among the most studied biomarkers are neutrophil gelatinase-associated lipocalin-2, kidney injury molecule-1, interleukin-18, cystatin C, N-acetyl-β-D-glucosaminidase, liver fatty-acid binding protein, and heat shock protein 72. Here, we reviewed and compared the sensitivity and specificity of each biomarker for the appropriate diagnosis of acute kidney injury, as well as its ability to stratify renal injury and to monitor a renoprotective pharmacologic strategy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetylglucosaminidase / urine
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Acute Kidney Injury / diagnosis*
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Acute Kidney Injury / urine*
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Acute-Phase Proteins / urine
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Biomarkers / urine*
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Cystatin C / urine
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Fatty Acid-Binding Proteins / urine
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HSP72 Heat-Shock Proteins / urine
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Hepatitis A Virus Cellular Receptor 1
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Humans
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Interleukin-18 / urine
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Lipocalin-2
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Lipocalins / urine
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Membrane Glycoproteins / urine
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Proto-Oncogene Proteins / urine
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Receptors, Virus
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Sensitivity and Specificity
Substances
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Acute-Phase Proteins
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Biomarkers
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Cystatin C
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Fatty Acid-Binding Proteins
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HAVCR1 protein, human
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HSP72 Heat-Shock Proteins
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Hepatitis A Virus Cellular Receptor 1
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Interleukin-18
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LCN2 protein, human
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Lipocalin-2
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Lipocalins
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Membrane Glycoproteins
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Proto-Oncogene Proteins
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Receptors, Virus
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Acetylglucosaminidase