Abstract
Inhibitor-1 has been shown to be phosphorylated in skeletal muscle in vivo. In normal fed animals the degree of phosphorylation was 31 +/- 7% and this value increases to 70 +/- 12% following an intravenous injection of adrenaline. The results imply that the phosphorylation of inhibitor-1 may be equally as important as the phosphorylation of phosphorylase kinase in elevating the levels of phosphorylase a. The role of inhibitor-1 in metabolism is discussed.
MeSH terms
-
Animals
-
Epinephrine / pharmacology*
-
Glycogen / metabolism*
-
Intracellular Signaling Peptides and Proteins
-
Kinetics
-
Muscle Proteins / isolation & purification
-
Muscle Proteins / physiology*
-
Muscles / drug effects
-
Muscles / enzymology*
-
Phosphoprotein Phosphatases / metabolism*
-
Phosphorylase Kinase / metabolism
-
Phosphorylase a / metabolism
-
Phosphorylase b / metabolism
-
Phosphorylation
-
Rabbits
Substances
-
Intracellular Signaling Peptides and Proteins
-
Muscle Proteins
-
protein phosphatase inhibitor-1
-
Glycogen
-
Phosphorylase a
-
Phosphorylase b
-
Phosphorylase Kinase
-
Phosphoprotein Phosphatases
-
Epinephrine