Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol

Leuk Res. 2012 Jul;36(7):936-8. doi: 10.1016/j.leukres.2012.03.024. Epub 2012 Apr 21.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Child
  • Child, Preschool
  • Chromosome Aberrations / chemically induced
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 21 / genetics
  • Clinical Trials as Topic / methods
  • Cohort Studies
  • Core Binding Factor Alpha 2 Subunit / genetics*
  • Denmark
  • ETS Translocation Variant 6 Protein
  • Finland
  • Humans
  • Iceland
  • Infant
  • Mutation / physiology
  • Norway
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy*
  • Prognosis
  • Proto-Oncogene Proteins c-ets / genetics*
  • Repressor Proteins / genetics*
  • Sweden
  • Translocation, Genetic / drug effects

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Proto-Oncogene Proteins c-ets
  • RUNX1 protein, human
  • Repressor Proteins