Vitamin D in kidney disease: pathophysiology and the utility of treatment

Rizwan A Qazi; Kevin J Martin

doi:10.1016/j.rdc.2012.03.011

Vitamin D in kidney disease: pathophysiology and the utility of treatment

Rheum Dis Clin North Am. 2012 Feb;38(1):115-23. doi: 10.1016/j.rdc.2012.03.011.

Authors

Rizwan A Qazi¹, Kevin J Martin

Affiliation

¹ Division of Nephrology, Saint Louis University, Saint Louis, MO 63110, USA. [email protected]

PMID: 22525847
DOI: 10.1016/j.rdc.2012.03.011

Abstract

CKD is associated with decreased vitamin D metabolites, both the storage form 25(OH)D and the active form 1,25-dihydroxyvitamin D. This contributes to hyperparathyroidism, and increased levels of PTH mobilize minerals from the skeleton and increase the risk for fractures. Treatment with vitamin D sterols efficiently reduces secondary hyperparathyroidism of CKD. Observational studies suggest survival and other potential benefits of vitamin D treatment in the CKD population. These observations need to be verified with controlled prospective trials.