Abstract
A nanostructured platform that combines electrospun TiO(2) nanofibers (TiNFs)-deposited substrate and cell-capture agent realizes significant capture of circulating tumor cells (CTCs). The enhanced local topographic interactions between the horizontally packed TiNFs deposited substrates and extracellular matrix scaffolds, in addition to anti-EpCAM/EpCAM biological recognition, contributes to the significantly enhanced capture efficiency compared to flat surfaces.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Neoplasm / metabolism
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Cell Adhesion Molecules / metabolism
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Cell Line, Tumor
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Colorectal Neoplasms / blood*
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Colorectal Neoplasms / pathology
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Epithelial Cell Adhesion Molecule
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HCT116 Cells
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HeLa Cells
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Humans
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Immunohistochemistry
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K562 Cells
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Nanofibers / chemistry*
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Neoplastic Cells, Circulating* / metabolism
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Povidone / chemistry
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Stomach Neoplasms / blood*
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Stomach Neoplasms / pathology
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Titanium / chemistry*
Substances
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Antigens, Neoplasm
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Cell Adhesion Molecules
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Epithelial Cell Adhesion Molecule
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titanium dioxide
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Titanium
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Povidone