Abstract
Objective:
This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC).
Methods:
CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction.
Results:
Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival.
Conclusions:
Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Autoantigens / genetics*
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Biomarkers, Tumor / genetics
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Carcinoma, Hepatocellular / genetics*
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Carcinoma, Hepatocellular / pathology
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Carcinoma, Hepatocellular / surgery
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Cell Line
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Cell Line, Tumor
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Female
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Gene Expression Profiling*
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Gene Expression Regulation, Neoplastic
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Hepatectomy / methods
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Humans
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Intracellular Signaling Peptides and Proteins
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Kaplan-Meier Estimate
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Liver / cytology
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Liver / metabolism*
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Liver Neoplasms / genetics*
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Liver Neoplasms / pathology
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Liver Neoplasms / surgery
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Male
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Membrane Proteins / genetics*
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Middle Aged
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Prognosis
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Autoantigens
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Biomarkers, Tumor
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CIP2A protein, human
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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RNA, Messenger