Replication: DNA building block synthesis on demand

Christian Holmberg; Olaf Nielsen

doi:10.1016/j.cub.2012.03.019

Replication: DNA building block synthesis on demand

Curr Biol. 2012 Apr 24;22(8):R271-2. doi: 10.1016/j.cub.2012.03.019.

Authors

Christian Holmberg¹, Olaf Nielsen

Affiliation

¹ Cell cycle and Genome Stability Group, Department of Biology, University of Copenhagen, Ole Maaløes vej 5, DK-2200 Copenhagen N, Denmark.

PMID: 22537629
DOI: 10.1016/j.cub.2012.03.019

Abstract

Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism*
Cell Cycle Proteins / metabolism*
DNA, Fungal / biosynthesis*
Proliferating Cell Nuclear Antigen / metabolism*
Ribonucleotide Reductases / metabolism*
Schizosaccharomyces pombe Proteins / metabolism*

Substances

Adaptor Proteins, Signal Transducing
Cdt2 protein, S pombe
Cell Cycle Proteins
DNA, Fungal
Proliferating Cell Nuclear Antigen
Schizosaccharomyces pombe Proteins
Spd1 protein, S pombe
Ribonucleotide Reductases