Reliability of the amplitude of low-frequency fluctuations in resting state fMRI in chronic schizophrenia

Psychiatry Res. 2012 Mar 31;201(3):253-5. doi: 10.1016/j.pscychresns.2011.09.012. Epub 2012 Apr 26.

Abstract

The resting state amplitude of low frequency fluctuations (ALFF) in functional magnetic resonance imaging has been shown to be reliable in healthy subjects, and to correlate with antipsychotic treatment response in antipsychotic-naïve schizophrenia patients. We found moderate to high test-retest stability of ALFF in chronically treated schizophrenia patients assessed twice over a median interval of 2.5 months.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Brain / blood supply*
  • Brain / pathology
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Oxygen / blood
  • Psychiatric Status Rating Scales
  • Reproducibility of Results
  • Rest / physiology*
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology
  • Young Adult

Substances

  • Oxygen