BEAMing up personalized medicine: mutation detection in blood

Clin Cancer Res. 2012 Jun 15;18(12):3209-11. doi: 10.1158/1078-0432.CCR-12-0871. Epub 2012 May 1.

Abstract

BEAMing is a feasible, accurate, and sensitive method for detection of PIK3CA mutations in circulating tumor DNA in blood. Mutation status of PIK3CA may change between primary tumor and recurrence. The results suggest a new approach for noninvasive determination of current mutation status in patients with metastatic disease.

MeSH terms

  • Breast Neoplasms / blood
  • Breast Neoplasms / genetics*
  • Class I Phosphatidylinositol 3-Kinases
  • DNA, Neoplasm / blood*
  • DNA, Neoplasm / genetics*
  • Female
  • Humans
  • Mutant Proteins / blood
  • Mutation
  • Neoplasm Metastasis / genetics
  • Phosphatidylinositol 3-Kinases / blood*
  • Phosphatidylinositol 3-Kinases / genetics*
  • Precision Medicine
  • Sensitivity and Specificity

Substances

  • DNA, Neoplasm
  • Mutant Proteins
  • Phosphatidylinositol 3-Kinases
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human