Introduction: Atypical polypoid adenomyoma (APA) is an uncommon uterine tumor which is composed of atypical endometrial glands and cellular smooth-muscle stroma. At present APA is categorized as a benign lesion and treated conservatively in the literatures. However, there are also several cases reported that progressed to endometrial endometrioid adenocarcinoma (EEC) till now. Here, we present two more rare cases of APA that may have undergone progression to EEC.
Materials: Two patients who had APA 6 and 4 years ago, respectively, and had ECC were reported.
Methods: The history of the two patients and the literatures were retrospectively reviewed.
Conclusions: The truth that APA may have a chance to progress to carcinoma suggests that APA is at least an indicator lesion for the development of EEC, and highlights that clinicians should carefully monitor the patients, and a meticulous follow-up examination is mandatory.