Abstract
Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antifungal Agents / toxicity
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Bacteria / drug effects
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Candida / drug effects*
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Cell Survival / drug effects
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Chemistry Techniques, Synthetic
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Hep G2 Cells
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Humans
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Hydrazines / chemical synthesis*
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Hydrazines / chemistry
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Hydrazines / pharmacology*
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Hydrazines / toxicity
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Hydrazines