Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects

Dokl Biochem Biophys. 2012 Mar-Apr:443:81-5. doi: 10.1134/S1607672912020068. Epub 2012 May 5.

Authors

E V Rudakova¹, G F Makhaeva, T G Galenko, A Yu Aksinenko, V B Sokolov, R J Richardson, I V Martynov

Affiliation

¹ Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severny pr. 1, Chernogolovka, Moscow oblast, 142432 Russia.

PMID: 22562631
DOI: 10.1134/S1607672912020068

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / adverse effects
Cholinesterase Inhibitors / pharmacology
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Esterases / antagonists & inhibitors*
Humans
Hydrophobic and Hydrophilic Interactions
Lactates / chemistry
Organophosphorus Compounds / adverse effects
Organophosphorus Compounds / chemistry*
Organophosphorus Compounds / pharmacology*
Phosphorylation
Structure-Activity Relationship*

Substances

Cholinesterase Inhibitors
Enzyme Inhibitors
Lactates
Organophosphorus Compounds
Esterases