Abstract
JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Genome, Viral*
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Molecular Sequence Data
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Mutation, Missense
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Point Mutation
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Porcine respiratory and reproductive syndrome virus / genetics*
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Porcine respiratory and reproductive syndrome virus / growth & development
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Porcine respiratory and reproductive syndrome virus / pathogenicity*
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RNA, Viral / genetics*
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Sequence Analysis, DNA*
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Sequence Deletion
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Serial Passage
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Swine
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Virulence