Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

Lisheng Wang; Yejun You; Songqing Wang; Xu Liu; Buming Liu; Jinni Wang; Xiao Lin; Mingsheng Chen; Gang Liang; Hua Yang

doi:10.1016/j.bmcl.2012.04.069

Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4100-2. doi: 10.1016/j.bmcl.2012.04.069. Epub 2012 Apr 24.

Authors

Lisheng Wang¹, Yejun You, Songqing Wang, Xu Liu, Buming Liu, Jinni Wang, Xiao Lin, Mingsheng Chen, Gang Liang, Hua Yang

Affiliation

¹ School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China. [email protected]

PMID: 22578453
DOI: 10.1016/j.bmcl.2012.04.069

Abstract

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis*
Alkaloids / pharmacology
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Colchicine / pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Mass Spectrometry
Matrines
Quinolizines / chemical synthesis*
Quinolizines / pharmacology
Spectrophotometry, Infrared
Structure-Activity Relationship

Substances

Alkaloids
Antineoplastic Agents
Quinolizines
Colchicine
Matrines