Abstract
In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD(50)). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD(50) and pharmacological activities of the synthesized compounds were reported.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemistry
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Analgesics / pharmacology
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Analgesics / toxicity
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / toxicity
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds / pharmacology
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Heterocyclic Compounds / toxicity
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Male
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Mice
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Microbial Sensitivity Tests
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Polycyclic Compounds / chemistry
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Polycyclic Compounds / pharmacology
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Pyridazines / chemistry
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Pyridazines / pharmacology*
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Pyridazines / toxicity
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Rats
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Structure-Activity Relationship
Substances
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Analgesics
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Anti-Infective Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Heterocyclic Compounds
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Polycyclic Compounds
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Pyridazines