Abstract
Three new clerodane-type diterpenoids with a rare sulfoxide group, cleidbrevoids A-C (1-3), were isolated from the twigs and leaves of Cleidion brevipetiolatum. Their structures were elucidated on the basis of spectroscopic methods and the absolute configuration of compounds 1 and 3 was determined by X-ray analysis. Compound 3 showed weak inhibitory against HIV-1.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Diterpenes, Clerodane / chemistry*
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Diterpenes, Clerodane / isolation & purification*
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Diterpenes, Clerodane / pharmacology
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HIV-1 / drug effects*
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Plant Stems / chemistry
Substances
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Antiviral Agents
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Diterpenes, Clerodane
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Plant Extracts
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cleidbrevoid A
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cleidbrevoid B
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cleidbrevoid C