Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules

Mol Divers. 2012 May;16(2):357-66. doi: 10.1007/s11030-012-9372-3. Epub 2012 May 15.

Abstract

A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / chemical synthesis*
  • Antidepressive Agents / chemistry
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Benzocycloheptenes / chemistry*
  • Female
  • Male
  • Mice
  • Models, Biological
  • Sesquiterpenes / chemistry*
  • Structure-Activity Relationship
  • Vinyl Compounds / chemistry*

Substances

  • Antidepressive Agents
  • Benzocycloheptenes
  • Sesquiterpenes
  • Vinyl Compounds
  • vinyl bromide
  • himachalene