On the road to combinations of targeted therapies: PPM1H phosphatase as a suppressor of trastuzumab resistance

Cancer Discov. 2011 Sep;1(4):285-6. doi: 10.1158/2159-8290.CD-11-0185.

Abstract

Lee-Hoeflich and colleagues use RNA interference screening to identify the serine/threonine phosphatase PPM1H as an inhibitor of trastuzumab resistance in vitro. This finding extends the molecular portrait of trastuzumab-resistant cells and provides a rationale when searching for potential therapeutic targets among regulators of PPM1H and/or its substrates.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal, Humanized / pharmacology*
  • Cyclin-Dependent Kinase Inhibitor p27 / genetics*
  • Female
  • Humans
  • Phosphoprotein Phosphatases / genetics*
  • Phosphoprotein Phosphatases / metabolism*
  • Trastuzumab

Substances

  • Antibodies, Monoclonal, Humanized
  • Cyclin-Dependent Kinase Inhibitor p27
  • PPM1H protein, human
  • Phosphoprotein Phosphatases
  • Trastuzumab