Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide

J Med Chem. 1990 Dec;33(12):3120-2. doi: 10.1021/jm00174a001.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaldehyde / blood
  • Alcohol Deterrents / metabolism*
  • Alcohol Deterrents / pharmacokinetics
  • Alcohol Deterrents / pharmacology
  • Aldehyde Dehydrogenase / antagonists & inhibitors
  • Biotransformation
  • Catalase / metabolism*
  • Cyanamide / metabolism*
  • Cyanamide / pharmacokinetics
  • Cyanamide / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mitochondria, Liver / enzymology
  • Nitrogen Oxides / metabolism*

Substances

  • Alcohol Deterrents
  • Nitrogen Oxides
  • Cyanamide
  • Catalase
  • Aldehyde Dehydrogenase
  • nitroxyl
  • Acetaldehyde