Abstract
A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants <6 months of age.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Azithromycin / pharmacology
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Azithromycin / therapeutic use
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Bordetella pertussis / drug effects*
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Bordetella pertussis / genetics
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Clarithromycin / pharmacology
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Clarithromycin / therapeutic use
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DNA Mutational Analysis
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Drug Resistance, Bacterial*
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Exchange Transfusion, Whole Blood
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Female
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Humans
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Infant, Newborn
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RNA, Ribosomal, 23S / genetics
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Treatment Outcome
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Whooping Cough / diagnosis*
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Whooping Cough / therapy
Substances
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RNA, Ribosomal, 23S
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Azithromycin
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Clarithromycin