Abstract
A new type of IMAC material, with ATP as the chelating ligand, was synthesized and applied to capture phosphopeptides. For the first time, the approach for phosphopeptide enrichment could provide selectivity under 5000-fold dilution by nonphosphopeptides, and sensitivity of on-target enrichment at 3 amol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / chemistry*
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Magnetite Nanoparticles / chemistry*
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Particle Size
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Phosphopeptides / chemistry*
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Surface Properties
Substances
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Magnetite Nanoparticles
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Organometallic Compounds
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Phosphopeptides
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Adenosine