6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein

ChemMedChem. 2012 Jul;7(7):1177-80. doi: 10.1002/cmdc.201200154. Epub 2012 May 21.

Authors

Glaucio Valdameri¹, Estelle Genoux-Bastide, Charlotte Gauthier, Basile Peres, Raphaël Terreux, Sheila M B Winnischofer, Maria E M Rocha, Attilio Di Pietro, Ahcène Boumendjel

Affiliation

¹ Mechanisms and Modulation of Drug Resistance Team, Institute of Biology and Chemistry of Proteins, BMSSI UMR 5086 CNRS/University of Lyon 1, 7 Passage du Vercors, 69367 Lyon, France.

PMID: 22615192
DOI: 10.1002/cmdc.201200154

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters / antagonists & inhibitors*
ATP-Binding Cassette Transporters / metabolism
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
Cell Survival / drug effects
Cells, Cultured
Chromones / chemical synthesis
Chromones / chemistry
Chromones / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HEK293 Cells
Humans
Molecular Structure
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / metabolism
Structure-Activity Relationship
Tryptamines / chemistry*

Substances

ABCG2 protein, human
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Antineoplastic Agents
Chromones
Neoplasm Proteins
Tryptamines
tryptamine