Advanced oxidation protein products as prognostic biomarkers for recovery from acute kidney injury after coronary artery bypass grafting

Biomarkers. 2012 Sep;17(6):507-12. doi: 10.3109/1354750X.2012.690103. Epub 2012 May 23.

Abstract

Recovery from acute kidney injury (AKI) is related to long-term prognosis. This study, involving 56 patients with AKI and 56 controls from a prospective cohort undergoing coronary artery bypass grafting (CABG), investigated the prognostic performance of serum levels of advanced oxidation protein products (AOPPs) for predicting non-recovered AKI and non-completely recovered AKI. AOPP levels increased significantly 7 days after surgery in patients with non-recovered or non-completely recovered AKI. Increased AOPP levels were associated with both types of poor recovery from AKI. Results from receiver-operating characteristic (ROC) curves demonstrated that AOPP levels had good prognostic value for predicting non-recovered and non-completely recovered AKI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / blood*
  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / physiopathology
  • Advanced Oxidation Protein Products / blood*
  • Aged
  • Biomarkers / blood
  • Case-Control Studies
  • Coronary Artery Bypass / adverse effects*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • ROC Curve
  • Recovery of Function*
  • Retrospective Studies
  • Stroke Volume
  • Ventricular Function, Left

Substances

  • Advanced Oxidation Protein Products
  • Biomarkers