Synthesis and antitumor activity of formononetin nitrogen mustard derivatives

Jie Ren; Hua-Jin Xu; Hong Cheng; Wen-Qun Xin; Xin Chen; Kun Hu

doi:10.1016/j.ejmech.2012.04.039

Synthesis and antitumor activity of formononetin nitrogen mustard derivatives

Eur J Med Chem. 2012 Aug:54:175-87. doi: 10.1016/j.ejmech.2012.04.039. Epub 2012 May 7.

Authors

Jie Ren¹, Hua-Jin Xu, Hong Cheng, Wen-Qun Xin, Xin Chen, Kun Hu

Affiliation

¹ School of Pharmaceutical Engineering & Life Science, Changzhou University, 1 Gehu Road, Changzhou, Jiangsu 213164, PR China.

PMID: 22633834
DOI: 10.1016/j.ejmech.2012.04.039

Abstract

A series of formononetin nitrogen mustard derivatives were synthesized and evaluated in vitro for their cytotoxicity against five cancer cell lines (SH-SY5Y, HCT-116, DU-145, Hela and SGC-7901). The pharmacological results showed that many of the new derivatives displayed more potent cytotoxicity than alkeran. Furthermore, compounds 6d and 6n could induce cell cycle arrest at G2/M phase and cell apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Cycle Checkpoints / drug effects
Cell Line, Tumor
Chemistry Techniques, Synthetic
Humans
Inhibitory Concentration 50
Isoflavones / chemistry*
Mechlorethamine / chemical synthesis*
Mechlorethamine / chemistry
Mechlorethamine / pharmacology*

Substances

Antineoplastic Agents
Isoflavones
formononetin
Mechlorethamine