Extracellular NAD(+): a danger signal hindering regulatory T cells

Sahil Adriouch; Friedrich Haag; Olivier Boyer; Michel Seman; Friedrich Koch-Nolte

doi:10.1016/j.micinf.2012.05.011

Extracellular NAD(+): a danger signal hindering regulatory T cells

Microbes Infect. 2012 Nov;14(14):1284-92. doi: 10.1016/j.micinf.2012.05.011. Epub 2012 May 24.

Authors

Sahil Adriouch¹, Friedrich Haag, Olivier Boyer, Michel Seman, Friedrich Koch-Nolte

Affiliation

¹ Inserm, U905, 22 boulevard Gambetta, F-76000 Rouen, Normandy, France. [email protected]

PMID: 22634347
DOI: 10.1016/j.micinf.2012.05.011

Abstract

Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Communication / immunology*
Cell Death / immunology
Extracellular Space / immunology
Humans
NAD / immunology*
T-Lymphocytes, Regulatory / immunology*

Substances

NAD