Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors

Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6672-5. doi: 10.1002/anie.201202000. Epub 2012 May 25.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • Combinatorial Chemistry Techniques / methods
  • Enzyme Inhibitors / chemistry*
  • Esters / chemistry*
  • Humans
  • Hypoxia-Inducible Factor-Proline Dioxygenases
  • Kinetics
  • Mass Spectrometry / methods
  • Nuclear Magnetic Resonance, Biomolecular / methods
  • Oxidation-Reduction
  • Procollagen-Proline Dioxygenase / antagonists & inhibitors*
  • Procollagen-Proline Dioxygenase / chemistry

Substances

  • Boronic Acids
  • Enzyme Inhibitors
  • Esters
  • EGLN1 protein, human
  • Procollagen-Proline Dioxygenase
  • Hypoxia-Inducible Factor-Proline Dioxygenases