Previous studies have shown that country income grouping is correlated with cigarette engineering. Cigarettes (N = 111 brands) were purchased during 2008-2010 from 11 low-, middle-, and high-income countries to assess physical dimensions and an array of cigarette design features. Mean ventilation varied significantly across low- (7.5%), middle- (15.3%), and high-income (26.2%) countries (P ≤ 0.001). Differences across income groups were also seen in cigarette length (P = 0.001), length of the tipping paper (P = 0.01), filter weight (P = 0.017), number of vent rows (P = 0.003), per-cigarette tobacco weight (P = 0.04), and paper porosity (P = 0.008). Stepwise linear regression showed ventilation and tobacco length as major predictors of ISO tar yields in low-income countries (P = 0.909, 0.047), while tipping paper (P < 0.001), filter length (P < 0.001), number of vent rows (P = 0.014), and per-cigarette weight (P = 0.015) were predictors of tar yields in middle-income countries. Ventilation (P < 0.001), number of vent rows (P = 0.009), per-cigarette weight (P < 0.001), and filter diameter (P = 0.004) predicted tar yields in high-income countries. Health officials must be cognizant of cigarette design issues to provide effective regulation of tobacco products.